Reference - Detail
| RRC ID | 38918 |
|---|---|
| Author | Ezawa K, Minato K, Dobashi K. |
| Title | Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines. |
| Journal | Biomed Pharmacother |
| Abstract |
We studied the direct anti-tumor effects of ubenimex on five human lung cancer cell lines; ABC-1, RERF-LC-OK, RERF-LC-MS (adenocarcinoma) and SQ-5, EBC-1 (squamous cell carcinoma). Ubenimex dose-dependently inhibited the growth of these cancer cell lines except RERF-LC-MS. The results indicated that lung squamous cell carcinoma cell lines were more sensitive to ubenimex than lung adenocarcinoma cell lines. Coincidentally, histological observation by Hematoxylin eosine (HE) staining revealed that ubenimex induced nuclear condensation and apoptic body in the cancer cell lines. Immunohistochemical study showed ubenimex-treated cells expressed LeY antigen which is a useful phenotypic marker predictive of apoptosis. The induction of DNA fragmentation was also observed in the ubenimex treated cancer cell lines by ELISA. We conclude that ubenimex exhibits its direct anti-tumor effect against non-small-cell lung cancer cell lines, more effectively against squamous carcinoma cell lines, through the induction of apoptosis. |
| Volume | 50(6-7) |
| Pages | 283-9 |
| Published | 1996-1-1 |
| DOI | 10.1016/0753-3322(96)84827-x |
| PII | 0753-3322(96)84827-X |
| PMID | 8952869 |
| MeSH | Adenocarcinoma / immunology Adenocarcinoma / pathology* Antibiotics, Antineoplastic / pharmacology* Apoptosis / drug effects* Carcinoma, Squamous Cell / immunology Carcinoma, Squamous Cell / pathology* Cell Division / drug effects DNA Fragmentation / drug effects Humans Leucine / analogs & derivatives* Leucine / pharmacology Lung Neoplasms / immunology Lung Neoplasms / pathology* Tumor Cells, Cultured / immunology Tumor Cells, Cultured / pathology Tumor Cells, Cultured / physiology |
| IF | 4.545 |
| Times Cited | 30 |
| WOS Category | PHARMACOLOGY & PHARMACY MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | SQ-5(RCB0110) |