論文 - 詳細
| RRC ID | 38933 |
|---|---|
| 著者 | Kudo I, Matsuzawa A, Imai K, Murakami M, Inoue K. |
| タイトル | Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells. |
| ジャーナル | J Lipid Mediat Cell Signal |
| Abstract |
When rat pheochromocytoma PC12 cells, which had differentiated into neuron-like cells following culture with nerve growth factor, were activated with glutamate, approximately 40% of their type II phospholipase A2 (PLA2) was released into the extracellular medium. Glutamate-stimulated secretion of dopamine from PC12 cells was suppressed by type II PLA2 inhibitors. Exogenous type II PLA2 added alone directly elicited release of dopamine from PC12 cells. Thus released type II PLA2 may be involved in the regulation of neurotransmitter exocytosis by PC12 cells. |
| 巻・号 | 14(1-3) |
| ページ | 25-31 |
| 公開日 | 1996-9-1 |
| DOI | 10.1016/0929-7855(96)01504-0 |
| PII | 0929-7855(96)01504-0 |
| PMID | 8906541 |
| MeSH | Animals Dopamine / metabolism* Exocytosis Glutamic Acid / pharmacology* PC12 Cells Phospholipases A / metabolism* Phospholipases A2 Rats |
| 引用数 | 10 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |