| RRC ID |
38939
|
| Author |
Suzuki T, Ohno N, Chiba N, Miura NN, Adachi Y, Yadomae T.
|
| Title |
Immunopharmacological activity of the purified insoluble glucan, zymocel, in mice.
|
| Journal |
J Pharm Pharmacol
|
| Abstract |
Although it has been established that soluble glucan in fungi is important to host defence against infection, the importance of insoluble glucans is not clear. We have examined the in-vivo immunopharmacological activity of the insoluble glucan, zymocel. Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia. Zymocel also showed anti-tumour activity against sarcoma 180 in mice and also enhanced TNF synthesis and hydrogen peroxide production by macrophage-like cell line in-vitro, i.e. resulted in direct macrophage activation. These results show that zymocel shows varied immunopharmacological activity; it is suggested that the administration of insoluble glucan induces the inflammatory response, the subsequent activation of the immune systems via the cytokine network, and direct macrophage activation.
|
| Volume |
48(12)
|
| Pages |
1243-8
|
| Published |
1996-12-1
|
| DOI |
10.1111/j.2042-7158.1996.tb03930.x
|
| PMID |
9004185
|
| MeSH |
Animals
Capillary Permeability / drug effects
Glucans / pharmacology*
Hydrogen Peroxide / metabolism
Macrophages, Peritoneal / drug effects
Male
Mice
Mice, Inbred ICR
Nitric Oxide / biosynthesis
Organ Size / drug effects
Phagocytosis / drug effects
Spleen / drug effects
Tumor Necrosis Factor-alpha / biosynthesis
|
| IF |
2.571
|
| Times Cited |
11
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
