Reference - Detail
| RRC ID | 38961 |
|---|---|
| Author | Kinoshita K, Waritani T, Noto M, Takizawa K, Minemoto Y, Nishikawa A, Ohkuma S. |
| Title | Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH. |
| Journal | FEBS Lett |
| Abstract |
PC12 cells growth-arrested with bafilomycin A1 died showing apoptotic chromatin condensation in the nuclei. The bafilomycin A1-induced chromatin condensation was preceded by neurite outgrowth (NOG), required higher concentrations of bafilomycin A1 than NOG, and was suppressed by cycloheximide and aurintricarboxylic acid. NH4Cl (10 mM), another acidotropic pH perturbing agent, neither induced apoptotic chromatin condensation by itself nor suppressed that induced by bafilomycin A1, suggesting that bafilomycin A1-induced apoptosis occurs independently of intracellular pH in PC12 cells. |
| Volume | 398(1) |
| Pages | 61-6 |
| Published | 1996-11-25 |
| DOI | 10.1016/s0014-5793(96)01182-9 |
| PII | S0014579396011829 |
| PMID | 8946954 |
| MeSH | Ammonium Chloride / pharmacology Animals Anti-Bacterial Agents / pharmacology* Apoptosis / drug effects* Aurintricarboxylic Acid / pharmacology Cell Division / drug effects Chromatin / drug effects Cycloheximide / pharmacology DNA Fragmentation / drug effects Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Hydrogen-Ion Concentration Macrolides* PC12 Cells / cytology PC12 Cells / drug effects* Protein Biosynthesis Protein Synthesis Inhibitors / pharmacology Proteins / drug effects Rats Time Factors |
| IF | 3.057 |
| Times Cited | 26 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |