論文 - 詳細
| RRC ID | 39058 |
|---|---|
| 著者 | Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T. |
| タイトル | Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy. |
| ジャーナル | Anticancer Res |
| Abstract |
Peripheral neuropathy (PN) is a major dose-limiting side-effect of microtubule-targeting agents (MTAs), considered to be induced by inhibition of axonal microtubules. Therefore, it was thought that a useful method for predicting the frequencies of severe sensory-PN (FPN) would be to evaluate the neurite-disrupting effects of MTAs. Using neurite outgrowth from neuron-like cell lines, we comprehensively evaluated the neurite-disrupting effects of several anti-cancer drugs including MTAs, and the reversibility of the effects of MTAs. MTAs that induce PN showed neurite-disrupting effects more strongly than MTAs and anticancer drugs that do not induce PN, but the effects were not related to the FPN. On the other hand, MTAs with high FPN exhibited lower reversibility than those with low FPN. These findings suggest that neurite-disrupting effects are associated with the incidence of PN, and the reversibility of the effects is associated with FPN. |
| 巻・号 | 35(12) |
| ページ | 6431-7 |
| 公開日 | 2015-12-1 |
| PII | 35/12/6431 |
| PMID | 26637853 |
| MeSH | Animals Antineoplastic Agents / adverse effects* Antineoplastic Agents / pharmacology* Brain Neoplasms / drug therapy* Brain Neoplasms / pathology* Cell Line, Tumor Humans Incidence Microtubules / drug effects* Neurites / drug effects* PC12 Cells Peripheral Nervous System Diseases / chemically induced* Peripheral Nervous System Diseases / pathology* Rats |
| IF | 1.994 |
| 引用数 | 3 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |