論文 - 詳細
| RRC ID | 39113 |
|---|---|
| 著者 | Suzuki M, Kase Y, Kanai T, Ando K. |
| タイトル | Correlation between cell death and induction of non-rejoining PCC breaks by carbon-ion beams. |
| ジャーナル | Adv Space Res |
| Abstract |
We have shown a correlation between cell death and induction of non-rejoining chromatin breaks in two normal human cells and three human tumor cell lines irradiated by carbon-ion beams and X rays. Non-rejoining chromatin breaks were measured by counting the number of remaining chromatin fragments detected by the premature chromosome condensation (PCC) technique. Carbon-ion beams were accelerated by the Heavy Ion Medical Accelerator in Chiba (HIMAC). The cells were irradiated by two different mono-LET beams (LET = 13 keV/micrometer and 77 keV/micrometer ) and 200 kV X rays. The RBE values of cell death for carbon-ion beams relative to X rays were 1.1 to 1.4 for 13 keV/micrometer beams and 2.5 to 2.9 for 77 keV/micrometer beams. The induction rate of non-rejoining PCC breaks per cell per Gy was found to be highest for the 77 keV/micrometer beams for all of the cell lines. The results found in this study show that there is a good correlation between cell death and induction of non-rejoining PCC breaks for these human cell lines. |
| 巻・号 | 22(4) |
| ページ | 561-8 |
| 公開日 | 1998-1-1 |
| DOI | 10.1016/s0273-1177(98)00078-7 |
| PMID | 11542786 |
| MeSH | Astrocytoma / pathology Brain Neoplasms / pathology Carbon* Cell Death Cell Survival / radiation effects Chromatin / radiation effects* Chromosome Breakage* Fibroblasts / radiation effects Glioblastoma / pathology Heavy Ions* Humans Linear Energy Transfer Lung / cytology Lung / embryology Melanoma, Amelanotic / pathology Particle Accelerators Relative Biological Effectiveness Skin Neoplasms / pathology Tumor Cells, Cultured / radiation effects X-Rays* |
| IF | 2.178 |
| 引用数 | 15 |
| WOS 分野 | ENGINEERING, AEROSPACE GEOSCIENCES, MULTIDISCIPLINARY ASTRONOMY & ASTROPHYSICS METEOROLOGY & ATMOSPHERIC SCIENCES GENETICS & HEREDITY |
| リソース情報 | |
| ヒト・動物細胞 | HFL-III(RCB0523) |