論文 - 詳細
| RRC ID | 39120 |
|---|---|
| 著者 | Fukunaga T, Furuno A, Hatsuzawa K, Tani K, Yamamoto A, Tagaya M. |
| タイトル | NSF is required for the brefeldin A-promoted disassembly of the Golgi apparatus. |
| ジャーナル | FEBS Lett |
| Abstract |
N-Ethylmaleimide-sensitive factor (NSF) is required for multiple pathways of vesicle-mediated protein transport. Microinjection of a monoclonal anti-NSF antibody almost completely blocked brefeldin A-promoted Golgi disassembly without affecting the rapid release of beta-COP, a subunit of the Golgi coat proteins (COPI), from the Golgi apparatus. Similar results were obtained using a dominant-negative NSF which is known to compete with endogenous NSF. The present results suggest that an NSF-mediated step is present in the brefeldin A-promoted disassembly of the Golgi apparatus. |
| 巻・号 | 435(2-3) |
| ページ | 237-40 |
| 公開日 | 1998-9-18 |
| DOI | 10.1016/s0014-5793(98)01081-3 |
| PII | S0014-5793(98)01081-3 |
| PMID | 9762917 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology Brefeldin A CHO Cells Carrier Proteins / metabolism* Cricetinae Cyclopentanes / pharmacology* Golgi Apparatus / drug effects Golgi Apparatus / metabolism* Golgi Apparatus / ultrastructure* Macrolides Microscopy, Electron N-Ethylmaleimide-Sensitive Proteins Protein Synthesis Inhibitors / pharmacology* Vesicular Transport Proteins* |
| IF | 3.057 |
| 引用数 | 14 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | NRK(RCB0043) |