Reference - Detail
| RRC ID | 39134 |
|---|---|
| Author | Sato T, Hashizume M, Hotta Y, Okahata Y. |
| Title | Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions. |
| Journal | Biometals |
| Abstract |
The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1 to S state. |
| Volume | 11(2) |
| Pages | 107-12 |
| Published | 1998-4-1 |
| DOI | 10.1023/a:1009273827598 |
| PMID | 9542064 |
| MeSH | Aluminum / pharmacology* Animals Cell Cycle / drug effects Cell Division / drug effects Cell Size / drug effects Cytoskeleton / drug effects HeLa Cells Humans Kinetics Melanoma, Experimental / drug therapy* Melanoma, Experimental / pathology* Metals, Rare Earth / pharmacology* Mice Tumor Cells, Cultured |
| IF | 2.479 |
| Times Cited | 35 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Hep G2(RCB0459) |