| RRC ID |
39189
|
| Author |
Kataoka H, Uchino H, Denda K, Kitamura N, Itoh H, Tsubouchi H, Nabeshima K, Koono M.
|
| Title |
Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa.
|
| Journal |
Cancer Lett
|
| Abstract |
Gene expression of hepatocyte growth factor activator inhibitor (HAI), a recently identified Kunitz-type serine proteinase inhibitor, was analyzed in a series of human colorectal carcinoma cell lines and in human colorectal tissues. All of the 14 cell lines derived from adenocarcinoma of the colorectum expressed HAI in vitro, whereas a colon carcinoma cell line of neuroendocrine origin did not. In vivo, HAI was consistently expressed in the normal colorectal mucosa. Although the expression of HAI mRNA was conserved in adenocarcinoma tissues of the colorectum, the levels of expression were decreased in the adenocarcinoma tissues compared to the normal counterparts. There was a tendency towards an inverse correlation, albeit not well defined, between the amounts of HAI mRNA and the tumor progression. Immunohistochemical study indicated that HAI protein is present predominantly on the surface of epithelial cells of the colon and the immunoreactivity was decreased in the adenocarcinoma cells.
|
| Volume |
128(2)
|
| Pages |
219-27
|
| Published |
1998-6-19
|
| DOI |
10.1016/s0304-3835(98)00067-6
|
| PII |
S0304-3835(98)00067-6
|
| PMID |
9683286
|
| MeSH |
Adult
Aged
Aged, 80 and over
Colon / metabolism*
Colorectal Neoplasms / metabolism*
Female
Humans
Immunohistochemistry
Intestinal Mucosa / metabolism*
Male
Membrane Glycoproteins / biosynthesis*
Middle Aged
Proteinase Inhibitory Proteins, Secretory
RNA, Messenger / metabolism
Rectum / metabolism*
Trypsin Inhibitor, Kunitz Soybean*
Tumor Cells, Cultured
|
| IF |
7.36
|
| Times Cited |
25
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
CW-2(RCB0778) |
