RRC ID 39208
Author Ando S, Nojima K, Majima H, Ishihara H, Suzuki M, Furusawa Y, Yamaguchi H, Koike S, Ando K, Yamauchi M, Kuriyama T.
Title Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line.
Journal Cancer Lett
Abstract Vascular endothelial growth factor (VEGF) is a multipotent cytokine which plays an important role in various angiogenic conditions as well as in some tumor behaviors. Here we examined the induction of VEGF mRNA by X-ray irradiation in a lung squamous cell carcinoma cell line (RERF-LC-AI). Irradiating the cells with 15 Gy X-rays significantly increased the mRNA expression up to 2.5-fold of control at a post-irradiation time of 16-24 h. The induction of VEGF mRNA by X-ray irradiation was completely blocked by treating cells with either genistein (Src tyrosine kinase inhibitor) or H7 (protein kinase C inhibitor). This suggests that the mechanism of induction might be concerned with the pathway which triggers Src tyrosine kinase of the cell surface and the protein kinase C pathway.
Volume 132(1-2)
Pages 75-80
Published 1998-10-23
DOI 10.1016/s0304-3835(98)00160-8
PII S0304-3835(98)00160-8
PMID 10397456
MeSH Antineoplastic Agents / pharmacology Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / pathology Endothelial Growth Factors / genetics* Gene Expression Regulation, Neoplastic / drug effects Gene Expression Regulation, Neoplastic / radiation effects Genistein / pharmacology Humans Lung Neoplasms / genetics Lung Neoplasms / pathology Lymphokines / genetics* RNA, Messenger / genetics* Time Factors Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / metabolism Tumor Cells, Cultured / radiation effects Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors X-Rays
IF 6.508
Times Cited 26
Human and Animal Cells