論文 - 詳細
| RRC ID | 39226 |
|---|---|
| 著者 | Shimada T, Matsumoto M, Tatsumi Y, Kanamaru A, Akira S. |
| タイトル | A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. |
| ジャーナル | FEBS Lett |
| Abstract |
To identify genes induced in activated macrophages, we screened a cDNA library prepared from the lipopolysaccharide (LPS)-treated cell line, RAW264, using the suppression subtractive hybridization technique. One of the clones isolated was dramatically induced by LPS in macrophages. The predicted protein sequence of this gene contains the domain unique to seven transmembrane receptors, and shows similarity with mouse C-C chemokine receptor 5 (CCR5). Therefore, we designated it LPS inducible C-C chemokine receptor related gene (L-CCR). Northern blot analysis revealed that L-CCR was specifically expressed in differentiated macrophages after LPS stimulation. These results show that L-CCR is a novel C-C chemokine receptor related gene induced by LPS in macrophages and may play an important role in inflammatory responses. |
| 巻・号 | 425(3) |
| ページ | 490-4 |
| 公開日 | 1998-4-3 |
| DOI | 10.1016/s0014-5793(98)00299-3 |
| PII | S0014-5793(98)00299-3 |
| PMID | 9563519 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cell Line Cloning, Molecular Gene Expression Regulation / genetics Immunity / immunology Lipopolysaccharides / pharmacology* Macrophages / chemistry* Mice Molecular Sequence Data RNA, Messenger / metabolism Receptors, CCR Receptors, CCR5 / chemistry Receptors, Chemokine / chemistry* Sequence Alignment Sequence Analysis, DNA |
| IF | 3.057 |
| 引用数 | 38 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |