論文 - 詳細
| RRC ID | 39231 |
|---|---|
| 著者 | Shige H, Ishikawa T, Suzukawa M, Nishiwaki M, Yamashita T, Nakajima K, Ito T, Higashi K, Ayaori M, Yonemura A, Nestel P, Nakamura H. |
| タイトル | Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages. |
| ジャーナル | Lipids |
| Abstract |
The effects of vitamin E on cholesteryl ester (CE) metabolism in J774 cells were examined. Pretreatment of J774 cells with vitamin E at concentrations above 50 microM significantly decreased acetylated low density lipoprotein (LDL)-induced incorporation of [14C]oleate into CE in cells in a dose-dependent manner. This was partly due to vitamin E also significantly inhibiting the uptake of [3H]CE-labeled acetylated LDL by J774 cells. A trend existed toward suppression of acyl-CoA:cholesterol acyltransferase (ACAT) activity in the cell lysate at high vitamin E concentration, but there was no effect on hydrolysis of CE. These data indicate that vitamin E reduces the uptake of modified LDL and suppresses ACAT activity, resulting in less cholesterol esterification in macrophages: a novel mechanism underlying the antiatherogenic properties of vitamin E. |
| 巻・号 | 33(12) |
| ページ | 1169-75 |
| 公開日 | 1998-12-1 |
| DOI | 10.1007/s11745-998-0320-9 |
| PMID | 9930402 |
| MeSH | Animals Cell Line Cholesterol / metabolism* Cholesterol Esters / metabolism Esterification Humans Hydrolysis Lipoproteins, LDL / metabolism* Macrophages / drug effects* Macrophages / enzymology Macrophages / metabolism Male Sterol O-Acyltransferase / metabolism Vitamin E / pharmacology* |
| IF | 1.919 |
| 引用数 | 14 |
| WOS 分野 | NUTRITION & DIETETICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |