論文 - 詳細
| RRC ID | 39232 |
|---|---|
| 著者 | Nagao Y, Yamashiro K, Hara N, Horisawa Y, Kato K, Uemura A. |
| タイトル | Oral-mucosal administration of IFN-alpha potentiates immune response in mice. |
| ジャーナル | J Interferon Cytokine Res |
| Abstract |
We studied the effects of oral-mucosal administration of murine interferon-alpha (Mu-IFN-alpha) on immune responses and infection with vaccinia virus (VV) in mice. When Mu-IFN-alpha was administered to sheep red blood cell (SRBC)-sensitized mice for 4 or 5 days, Mu-IFN-alpha significantly enhanced delayed-type hypersensitivity (DTH) and antibody production, with maximum enhancement of each at 1 IU/body. To investigate the antiviral effect of oral-mucosal Mu-IFN-alpha, mice were infected with VV, and Mu-IFN-alpha was administered for 15 days. Pocks were observed in the tail skin of infected mice, and Mu-IFN-alpha at doses of 1, 10, and 100 IU/body significantly suppressed pock formation. Also, VV-specific cytotoxic T cells (CTL) were observed in the spleen from the same mice at 7 days after infection, and Mu-IFN-alpha enhanced CTL activity at doses above 1 IU/body. These results suggest that the oral-mucosal Mu-IFN-alpha may have potentiating effects on cellular and humoral immune responses, which may contribute to its effects against VV. |
| 巻・号 | 18(9) |
| ページ | 661-6 |
| 公開日 | 1998-9-1 |
| DOI | 10.1089/jir.1998.18.661 |
| PMID | 9781804 |
| MeSH | Administration, Oral Animals Antibody Formation Antiviral Agents / therapeutic use* Hypersensitivity, Delayed / immunology Interferon-alpha / therapeutic use* Male Mice Mice, Inbred C3H Mouth Mucosa / drug effects T-Lymphocytes, Cytotoxic / immunology Vaccinia / drug therapy* |
| IF | 2.032 |
| 引用数 | 17 |
| WOS 分野 | IMMUNOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | L929 |