| RRC ID |
39232
|
| 著者 |
Nagao Y, Yamashiro K, Hara N, Horisawa Y, Kato K, Uemura A.
|
| タイトル |
Oral-mucosal administration of IFN-alpha potentiates immune response in mice.
|
| ジャーナル |
J Interferon Cytokine Res
|
| Abstract |
We studied the effects of oral-mucosal administration of murine interferon-alpha (Mu-IFN-alpha) on immune responses and infection with vaccinia virus (VV) in mice. When Mu-IFN-alpha was administered to sheep red blood cell (SRBC)-sensitized mice for 4 or 5 days, Mu-IFN-alpha significantly enhanced delayed-type hypersensitivity (DTH) and antibody production, with maximum enhancement of each at 1 IU/body. To investigate the antiviral effect of oral-mucosal Mu-IFN-alpha, mice were infected with VV, and Mu-IFN-alpha was administered for 15 days. Pocks were observed in the tail skin of infected mice, and Mu-IFN-alpha at doses of 1, 10, and 100 IU/body significantly suppressed pock formation. Also, VV-specific cytotoxic T cells (CTL) were observed in the spleen from the same mice at 7 days after infection, and Mu-IFN-alpha enhanced CTL activity at doses above 1 IU/body. These results suggest that the oral-mucosal Mu-IFN-alpha may have potentiating effects on cellular and humoral immune responses, which may contribute to its effects against VV.
|
| 巻・号 |
18(9)
|
| ページ |
661-6
|
| 公開日 |
1998-9-1
|
| DOI |
10.1089/jir.1998.18.661
|
| PMID |
9781804
|
| MeSH |
Administration, Oral
Animals
Antibody Formation
Antiviral Agents / therapeutic use*
Hypersensitivity, Delayed / immunology
Interferon-alpha / therapeutic use*
Male
Mice
Mice, Inbred C3H
Mouth Mucosa / drug effects
T-Lymphocytes, Cytotoxic / immunology
Vaccinia / drug therapy*
|
| IF |
2.032
|
| 引用数 |
17
|
|
WOS 分野
|
IMMUNOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
L929 |
