Reference - Detail
|Author||Chang L, Tanaka T, Umesaki N, Ogita S.|
|Title||Differential apoptotic susceptibility to anti-Fas IgM and anticancer drugs in a human endometrial adenocarcinoma cell line HHUA on laminin and type I collagen.|
|Journal||Osaka City Med J|
Apoptotic susceptibility of epithelial cells is known to be regulated by cell adhesions to basement membranes. In this study differences in anticancer drug-sensitivities of early and advanced endometrial adenocarcinomas were examined by using highly-differentiated human endometrial adenocarcinoma cell line, HHUA, whose apoptotic susceptibility was hypothesized to be modulated by extracellular matrices. The cells express high levels of laminin receptors and laminin suppressed Fas-mediated apoptosis of the cells. However laminin did not show any effect on apoptotic susceptibility to 4 anticancer drugs. These results suggest that there is little variation in drug-sensitivity associated with disruption of endometrial stromal tissue, and that pathological staging of endometrial carcinoma is not likely to have any relation to drug sensitivity.
|MeSH||Adenocarcinoma / pathology Adenocarcinoma / physiopathology* Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Collagen / pharmacology Drug Resistance Endometrial Neoplasms / pathology Endometrial Neoplasms / physiopathology* Female Humans Immunoglobulin M / immunology Immunoglobulin M / pharmacology* Laminin / pharmacology* Tumor Cells, Cultured fas Receptor / immunology*|
|Human and Animal Cells|