RRC ID |
39281
|
著者 |
Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M.
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タイトル |
Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice.
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ジャーナル |
Jpn J Pharmacol
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Abstract |
We investigated the effect of the water extract of Cordyceps sinensis (WECS) on liver metastasis of Lewis lung carcinoma (LLC) and B16 melanoma (B16) cells in mice. C57BL/6 mice were given a s.c. injection of LLC and B16 cells and sacrificed 20 and 26 days after tumor inoculation, respectively. WECS was daily administered p.o. to the mice in a dose of 100 mg/kg body weight (wt.) in the experiment of LLC and in a dose of 100 or 200 mg/kg body wt. in the experiment of B16 from one week before tumor inoculation to one day before the date of sacrifice. The tumor cells increased in the thigh in LLC-inoculated mice and in the footpad in B16-inoculated mice. The relative liver wt. of the tumor-inoculated mice significantly increased as compared to that of the normal mice due to the tumor metastasis, as verified by the hematoxylin-eosin staining pathological study in the LLC experiment. The relative liver wt. of the WECS-administered mice significantly decreased relative to that of the control mice in both the LLC and B16 experiments. WECS showed a strong cytotoxicity against LLC and B16 cells, while cordycepin (3'-deoxyadenosine), an active component of WECS, was not cytotoxic against these cells. These findings suggest that WECS has an anti-metastatic activity that is probably due to components other than cordycepin.
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巻・号 |
79(3)
|
ページ |
335-41
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公開日 |
1999-3-1
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DOI |
10.1254/jjp.79.335
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PMID |
10230862
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MeSH |
Animals
Body Weight / drug effects
Carcinoma, Lewis Lung / secondary*
Cell Count
Cell Division / drug effects
Drugs, Chinese Herbal / pharmacology*
Female
Hypocreales / chemistry*
Liver / drug effects
Liver / pathology
Liver Neoplasms, Experimental / pathology
Liver Neoplasms, Experimental / secondary*
Melanoma, Experimental / secondary*
Mice
Mice, Inbred C57BL
Organ Size / drug effects
Tumor Cells, Cultured / cytology
Tumor Cells, Cultured / drug effects
Weight Gain / drug effects
|
引用数 |
58
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
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リソース情報 |
ヒト・動物細胞 |
LLC(RCB0558) |