論文 - 詳細
| RRC ID | 39281 |
|---|---|
| 著者 | Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M. |
| タイトル | Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. |
| ジャーナル | Jpn J Pharmacol |
| Abstract |
We investigated the effect of the water extract of Cordyceps sinensis (WECS) on liver metastasis of Lewis lung carcinoma (LLC) and B16 melanoma (B16) cells in mice. C57BL/6 mice were given a s.c. injection of LLC and B16 cells and sacrificed 20 and 26 days after tumor inoculation, respectively. WECS was daily administered p.o. to the mice in a dose of 100 mg/kg body weight (wt.) in the experiment of LLC and in a dose of 100 or 200 mg/kg body wt. in the experiment of B16 from one week before tumor inoculation to one day before the date of sacrifice. The tumor cells increased in the thigh in LLC-inoculated mice and in the footpad in B16-inoculated mice. The relative liver wt. of the tumor-inoculated mice significantly increased as compared to that of the normal mice due to the tumor metastasis, as verified by the hematoxylin-eosin staining pathological study in the LLC experiment. The relative liver wt. of the WECS-administered mice significantly decreased relative to that of the control mice in both the LLC and B16 experiments. WECS showed a strong cytotoxicity against LLC and B16 cells, while cordycepin (3'-deoxyadenosine), an active component of WECS, was not cytotoxic against these cells. These findings suggest that WECS has an anti-metastatic activity that is probably due to components other than cordycepin. |
| 巻・号 | 79(3) |
| ページ | 335-41 |
| 公開日 | 1999-3-1 |
| DOI | 10.1254/jjp.79.335 |
| PMID | 10230862 |
| MeSH | Animals Body Weight / drug effects Carcinoma, Lewis Lung / secondary* Cell Count Cell Division / drug effects Drugs, Chinese Herbal / pharmacology* Female Hypocreales / chemistry* Liver / drug effects Liver / pathology Liver Neoplasms, Experimental / pathology Liver Neoplasms, Experimental / secondary* Melanoma, Experimental / secondary* Mice Mice, Inbred C57BL Organ Size / drug effects Tumor Cells, Cultured / cytology Tumor Cells, Cultured / drug effects Weight Gain / drug effects |
| 引用数 | 58 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |