| RRC ID |
39303
|
| 著者 |
Kurimoto M, Endo S, Hirashima Y, Hamada H, Ogiichi T, Takaku A.
|
| タイトル |
Growth inhibition and radiosensitization of cultured glioma cells by nitric oxide generating agents.
|
| ジャーナル |
J Neurooncol
|
| Abstract |
The authors examined the effect of nitric oxide (NO) generating agents on the growth and radiosensitivity of cultured glioma cells. Three glioma, rat C6, and human T98G and U87 cell lines were treated with the NO generating agents, S-nitroso-N-acetyl-penicillamine (SNAP) or sodium nitroprusside (SNP). These agents released NO in the cell culture media and inhibited the growth of the glioma cells. Growth-inhibition was attenuated by hemoglobin, a known inhibitor of NO, suggesting it is mediated by NO. When C6 and T98G cells were irradiated in the presence of SNAP or SNP at 100 microM, radiosensitization was observed. SNAP at 100 microM exhibited a sensitizer enhancement ratio (SER) of 1.4 for C6 cells and 1.8 for T98G cells. SNP at 100 microM only radiosensitized T98G cells with a SER of 1.9. The effect of SNP on radiosensitization of C6 cells was unclear. We conclude that NO generating agents are potential growth inhibitors and radiosensitizers for malignant glioma cells. NO mediated radiosensitization of glioma cells by NO generating agents may offer a new therapeutic approach for malignant glioma.
|
| 巻・号 |
42(1)
|
| ページ |
35-44
|
| 公開日 |
1999-3-1
|
| DOI |
10.1023/a:1006160305294
|
| PMID |
10360477
|
| MeSH |
Animals
Brain Neoplasms / pathology*
Cell Division / drug effects
Cell Survival / drug effects
Cell Survival / radiation effects*
Dose-Response Relationship, Radiation
Glioma / pathology*
Humans
Kinetics
Nitric Oxide Donors / toxicity*
Nitrites / metabolism
Nitroprusside / toxicity*
Penicillamine / analogs & derivatives*
Penicillamine / toxicity
Radiation-Sensitizing Agents / toxicity*
Rats
S-Nitroso-N-Acetylpenicillamine
Time Factors
Tumor Cells, Cultured
|
| IF |
3.267
|
| 引用数 |
45
|
|
WOS 分野
|
CLINICAL NEUROLOGY
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
U-87 MG(RCB0419) |
