| RRC ID |
39328
|
| Author |
Maekawa T, Waki S, Okada A, Fukui H, Kinoshita Y, Chiba T.
|
| Title |
Midkine gene expression in the healing process of gastric ulcer.
|
| Journal |
J Lab Clin Med
|
| Abstract |
Midkine is a newly cloned growth-promoting factor for fibroblastic cells. This study was performed to investigate the possible role of midkine in the stomach. Rats with acute or chronic gastric mucosal lesions were used. Histologically, acute mucosal lesions are not accompanied by the formation of granulation tissue; conversely, chronic mucosal lesions are accompanied by the formation of granulation tissue. The expression of the midkine gene was found in the normal intact gastrointestinal tract, especially the submucosal and muscle layers. Midkine mRNA increased during the healing stage of chronic gastric ulcer accompanied by a fibroblastic reaction. Furthermore, the fibroblast cell line MRC-5 expressed midkine mRNA strongly. Therefore, midkine may have some role in the healing of gastric deep ulcers that is accompanied by fibroblast proliferation.
|
| Volume |
133(4)
|
| Pages |
349-52
|
| Published |
1999-4-1
|
| DOI |
10.1016/s0022-2143(99)90065-3
|
| PII |
S0022-2143(99)90065-3
|
| PMID |
10218765
|
| MeSH |
Acetic Acid
Animals
Carrier Proteins / genetics*
Carrier Proteins / pharmacology
Carrier Proteins / physiology
Cell Division / drug effects
Cell Line
Cytokines*
Fibroblasts / metabolism
Gastric Mucosa / metabolism
Gastric Mucosa / pathology
Gene Expression*
Granulation Tissue / metabolism
Male
Midkine
Muscle, Smooth / metabolism
Nerve Growth Factors / genetics*
Nerve Growth Factors / pharmacology
Nerve Growth Factors / physiology
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Stomach Ulcer / chemically induced
Stomach Ulcer / metabolism*
Wound Healing
|
| Times Cited |
7
|
|
WOS Category
|
MEDICAL LABORATORY TECHNOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Human and Animal Cells |
RGM1(RCB0876)
MRC-5 |
