Reference - Detail
| RRC ID | 39328 |
|---|---|
| Author | Maekawa T, Waki S, Okada A, Fukui H, Kinoshita Y, Chiba T. |
| Title | Midkine gene expression in the healing process of gastric ulcer. |
| Journal | J Lab Clin Med |
| Abstract |
Midkine is a newly cloned growth-promoting factor for fibroblastic cells. This study was performed to investigate the possible role of midkine in the stomach. Rats with acute or chronic gastric mucosal lesions were used. Histologically, acute mucosal lesions are not accompanied by the formation of granulation tissue; conversely, chronic mucosal lesions are accompanied by the formation of granulation tissue. The expression of the midkine gene was found in the normal intact gastrointestinal tract, especially the submucosal and muscle layers. Midkine mRNA increased during the healing stage of chronic gastric ulcer accompanied by a fibroblastic reaction. Furthermore, the fibroblast cell line MRC-5 expressed midkine mRNA strongly. Therefore, midkine may have some role in the healing of gastric deep ulcers that is accompanied by fibroblast proliferation. |
| Volume | 133(4) |
| Pages | 349-52 |
| Published | 1999-4-1 |
| DOI | 10.1016/s0022-2143(99)90065-3 |
| PII | S0022-2143(99)90065-3 |
| PMID | 10218765 |
| MeSH | Acetic Acid Animals Carrier Proteins / genetics* Carrier Proteins / pharmacology Carrier Proteins / physiology Cell Division / drug effects Cell Line Cytokines* Fibroblasts / metabolism Gastric Mucosa / metabolism Gastric Mucosa / pathology Gene Expression* Granulation Tissue / metabolism Male Midkine Muscle, Smooth / metabolism Nerve Growth Factors / genetics* Nerve Growth Factors / pharmacology Nerve Growth Factors / physiology RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Stomach Ulcer / chemically induced Stomach Ulcer / metabolism* Wound Healing |
| Times Cited | 7 |
| WOS Category | MEDICAL LABORATORY TECHNOLOGY MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RGM1(RCB0876) MRC-5 |