| RRC ID |
39384
|
| 著者 |
Kono T, Watanabe M, Koyama K, Kishimoto T, Fukushima S, Sugimura T, Wakabayashi K.
|
| タイトル |
Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Pierisin, a protein purified from pupae of the cabbage butterfly, Pieris rapae, exhibits cytotoxic effects against the human gastric cancer TMK-1 cell line, inducing apoptosis. The present study was performed to determine whether pierisin might exert a similar influence on nine other human cancer cell lines and human umbilical vein endothelial cells (HUVECs). Pierisin showed cytotoxic effects in all the human cells tested, with IC50 values ranging from 0.043 ng/ml to 150 ng/ml. Among the target cells, the cervical carcinoma cell line, HeLa, was the most sensitive to pierisin, showing a 1000-fold less IC50 value than that of HUVECs. While pierisin clearly induced apoptotic cell death in most cancer cell lines and HUVECs, the pathway appeared to be probably different from that involving anti-Fas, TNF-alpha and p53. Pierisin may thus be a promising new candidate for cancer therapy.
|
| 巻・号 |
137(1)
|
| ページ |
75-81
|
| 公開日 |
1999-3-22
|
| DOI |
10.1016/s0304-3835(98)00346-2
|
| PII |
S0304-3835(98)00346-2
|
| PMID |
10376796
|
| MeSH |
ADP Ribose Transferases
Animals
Apoptosis
Butterflies / chemistry
Cytotoxins / pharmacology*
Drug Screening Assays, Antitumor
HeLa Cells / drug effects
Humans
Insect Proteins / pharmacology*
Tumor Cells, Cultured / drug effects
|
| IF |
7.36
|
| 引用数 |
37
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
CW-2(RCB0778)
HeLa(RCB0007)
Hep G2(RCB0459)
A549(RCB0098)
T24(RCB0431) |
