| RRC ID |
39393
|
| 著者 |
Kawamoto M, Shichijo S, Imai Y, Imaizumi T, Koga T, Yanaga H, Itoh K.
|
| タイトル |
Expression of the SART-1 tumor rejection antigen in breast cancer.
|
| ジャーナル |
Int J Cancer
|
| Abstract |
We investigated in breast cancers the expression of the SART-1 gene encoding tumor rejection antigens. SART-1 mRNA was expressed in all of the samples tested. The SART-1(800) antigen was detectable in 20 of 50 (40%) breast cancer tissues and all breast cancer cell lines tested, but not in normal breast tissues. The SART-1(800)+ breast cancer cells transfected with HLA-A2601 or HLA-A2402 cDNA were recognized by the HLA-A26-restricted and SART-1-specific cytotoxic T lymphocytes (CTLs) or the HLA-A24-restricted and SART-1-specific CTLs, respectively. Among the 20 SART-1(800)+ tumors, 9 or 8 tumors expressed estrogen receptor or progesterone receptor, respectively. Therefore, the patients with HLA-A26 or -A24 haplotype might be appropriate candidates for specific immunotherapy with the SART-1 peptides independently or in combination with hormone therapy.
|
| 巻・号 |
80(1)
|
| ページ |
64-7
|
| 公開日 |
1999-1-5
|
| DOI |
10.1002/(sici)1097-0215(19990105)80:1<64::aid-ijc13>3.0.co;2-7
|
| PII |
10.1002/(SICI)1097-0215(19990105)80:1<64::AID-IJC13>3.0.CO;2-7
|
| PMID |
9935232
|
| MeSH |
Antigens, Neoplasm / analysis
Breast / metabolism
Breast Neoplasms / genetics*
Breast Neoplasms / immunology
Breast Neoplasms / surgery
Carcinoma / genetics
Carcinoma / pathology
Carcinoma / surgery
Cytotoxicity, Immunologic
DNA-Binding Proteins / genetics
Female
HLA-A Antigens / biosynthesis
HLA-A Antigens / genetics
Humans
Neoplasm Proteins / analysis
Neoplasm Proteins / genetics*
RNA, Messenger / analysis
RNA, Messenger / genetics
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Recombinant Proteins / biosynthesis
Ribonucleoproteins, Small Nuclear*
Transcription, Genetic*
Transfection
Tumor Cells, Cultured
|
| IF |
5.145
|
| 引用数 |
25
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
OCUB-M(RCB0881)
OCUB-F(RCB0882) |
