RRC ID 39393
Author Kawamoto M, Shichijo S, Imai Y, Imaizumi T, Koga T, Yanaga H, Itoh K.
Title Expression of the SART-1 tumor rejection antigen in breast cancer.
Journal Int J Cancer
Abstract We investigated in breast cancers the expression of the SART-1 gene encoding tumor rejection antigens. SART-1 mRNA was expressed in all of the samples tested. The SART-1(800) antigen was detectable in 20 of 50 (40%) breast cancer tissues and all breast cancer cell lines tested, but not in normal breast tissues. The SART-1(800)+ breast cancer cells transfected with HLA-A2601 or HLA-A2402 cDNA were recognized by the HLA-A26-restricted and SART-1-specific cytotoxic T lymphocytes (CTLs) or the HLA-A24-restricted and SART-1-specific CTLs, respectively. Among the 20 SART-1(800)+ tumors, 9 or 8 tumors expressed estrogen receptor or progesterone receptor, respectively. Therefore, the patients with HLA-A26 or -A24 haplotype might be appropriate candidates for specific immunotherapy with the SART-1 peptides independently or in combination with hormone therapy.
Volume 80(1)
Pages 64-7
Published 1999-1-5
DOI 10.1002/(sici)1097-0215(19990105)80:1<64::aid-ijc13>3.0.co;2-7
PII 10.1002/(SICI)1097-0215(19990105)80:1<64::AID-IJC13>3.0.CO;2-7
PMID 9935232
MeSH Antigens, Neoplasm / analysis Breast / metabolism Breast Neoplasms / genetics* Breast Neoplasms / immunology Breast Neoplasms / surgery Carcinoma / genetics Carcinoma / pathology Carcinoma / surgery Cytotoxicity, Immunologic DNA-Binding Proteins / genetics Female HLA-A Antigens / biosynthesis HLA-A Antigens / genetics Humans Neoplasm Proteins / analysis Neoplasm Proteins / genetics* RNA, Messenger / analysis RNA, Messenger / genetics Receptors, Estrogen / analysis Receptors, Progesterone / analysis Recombinant Proteins / biosynthesis Ribonucleoproteins, Small Nuclear* Transcription, Genetic* Transfection Tumor Cells, Cultured
IF 5.145
Times Cited 25
Human and Animal Cells OCUB-M(RCB0881) OCUB-F(RCB0882)