RRC ID 39407
著者 Hamada K, Mikasa K, Yunou Y, Kurioka T, Majima T, Narita N, Kita E.
タイトル Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer.
ジャーナル Chemotherapy
Abstract Clarithromycin (CAM) increased the median survival of patients with unresectable non-small-cell lung cancer who had received chemotherapy and/or radiotherapy [Chemotherapy 1997;43:288-296]. The present study was performed to ascertain whether CAM alone exhibits an antitumor effect against Lewis lung carcinoma (LLC) and to analyze the nature of its adjuvant effect on LLC-inoculated C57BL/6 mice. CAM at 10 mg/kg/day retarded the growth of subcutaneously inoculated LLC cells; consequently, the mean survival time of mice with LLC increased. This treatment was also effective in reducing the number of tumor nodules in the lung after intravenous inoculation with LLC cells. When tumor-bearing mice received an intravenous injection of vindesine sulfate (7 mg/kg) and cisplatin (6 mg/kg) 7 days after tumor inoculation, the chemotherapeutic effect was significantly enhanced by CAM treatment when it started 7 days after chemotherapy, but not when it started the day after chemotherapy. The delayed initiation of CAM treatment resulted in the enhancement of natural killer cell activity and CD8+ T cell cytotoxicity and increased the number of interferon-gamma-producing T cells and interleukin-4-producing T cells. These findings indicate that CAM can exhibit an antitumor effect by itself and also induce the well-balanced expansion of helper T cell subsets in tumor-bearing mice recovering from the immunosuppression caused by chemotherapy. CAM may therefore be a promising adjuvant drug in anticancer chemotherapy, and treatment with this macrolide should be initiated at some interval after basic cancer therapy.
巻・号 46(1)
ページ 49-61
公開日 2000-1-1
DOI 10.1159/000007256
PII 7256
PMID 10601798
MeSH Animals Anti-Bacterial Agents / pharmacology* Carcinoma, Lewis Lung / drug therapy* Carcinoma, Lewis Lung / immunology Carcinoma, Lewis Lung / metabolism Chemotherapy, Adjuvant Clarithromycin / pharmacology* Cytotoxicity, Immunologic / drug effects Dose-Response Relationship, Drug Drug Administration Schedule Female Interferon-gamma / biosynthesis Interleukin-4 / biosynthesis Killer Cells, Natural / drug effects Killer Cells, Natural / immunology Mice Mice, Inbred C57BL Spleen T-Lymphocytes / drug effects T-Lymphocytes / immunology
IF 1.641
引用数 40
WOS 分野 PHARMACOLOGY & PHARMACY ONCOLOGY
リソース情報
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