RRC ID 39423
著者 Matsunaga Y, Nakajima K, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T.
タイトル A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
ジャーナル Biosci Biotechnol Biochem
Abstract The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.
巻・号 76(11)
ページ 2168-72
公開日 2012-1-1
DOI 10.1271/bbb.120540
PII DN/JST.JSTAGE/bbb/120540
PMID 23132577
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation* Insulins / genetics Insulins / metabolism* Sequence Deletion Transcription, Genetic
IF 1.516
引用数 11
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm790 tm339