RRC ID |
39423
|
著者 |
Matsunaga Y, Nakajima K, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T.
|
タイトル |
A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.
|
巻・号 |
76(11)
|
ページ |
2168-72
|
公開日 |
2012-1-1
|
DOI |
10.1271/bbb.120540
|
PII |
DN/JST.JSTAGE/bbb/120540
|
PMID |
23132577
|
MeSH |
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / genetics*
Caenorhabditis elegans Proteins / metabolism*
Gene Expression Regulation*
Insulins / genetics
Insulins / metabolism*
Sequence Deletion
Transcription, Genetic
|
IF |
1.516
|
引用数 |
11
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
線虫 |
tm790
tm339 |