Reference - Detail
| RRC ID | 39458 |
|---|---|
| Author | Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. |
| Title | Isolation of furocoumarins from bergamot fruits as HL-60 differentiation-inducing compounds. |
| Journal | J Agric Food Chem |
| Abstract |
The HL-60 differentiation-inducing compounds in bergamot fruits were isolated with column chromatography and identified as bergamottin, bergapten, and citropten by (1)H and (13)C NMR. Their HL-60 differentiation-inducing activity was measured by examining nitro blue tetrazolium (NBT) reducing, nonspecific acid esterase (NSE), specific esterase (SE), and phagocytic activities, and bergamottin showed the strongest activity among the coumarins isolated from bergamot fruits. The structure-activity relationship obtained from HL-60 differentiation assay suggests that hydrophobicity of furocoumarins is correlated with their activity. |
| Volume | 47(10) |
| Pages | 4073-8 |
| Published | 1999-10-1 |
| DOI | 10.1021/jf990155u |
| PII | jf990155u |
| PMID | 10552768 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Cell Differentiation / drug effects Chromatography, High Pressure Liquid Fruit / chemistry* Furocoumarins / chemistry Furocoumarins / isolation & purification* Furocoumarins / pharmacology* HL-60 Cells / cytology HL-60 Cells / drug effects* Humans Magnetic Resonance Spectroscopy Structure-Activity Relationship |
| IF | 4.192 |
| Times Cited | 27 |
| WOS Category | AGRICULTURE, MULTIDISCIPLINARY CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |