| RRC ID |
39463
|
| Author |
Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M, Takemura Y, Ju-ichi M, Ito C, Furukawa H.
|
| Title |
The antiproliferative effect of acridone alkaloids on several cancer cell lines.
|
| Journal |
J Nat Prod
|
| Abstract |
Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure-activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-1 and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones.
|
| Volume |
62(4)
|
| Pages |
587-9
|
| Published |
1999-4-1
|
| DOI |
10.1021/np980504z
|
| PII |
np980504z
|
| PMID |
10217715
|
| MeSH |
Acridines / chemistry
Acridines / isolation & purification
Acridines / pharmacology*
Acridones
Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Mice
Structure-Activity Relationship
Tumor Cells, Cultured
|
| IF |
3.782
|
| Times Cited |
44
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
PLANT SCIENCES
|
| Resource |
| Human and Animal Cells |
A549(RCB0098)
B16 melanoma 4A5(RCB0557)
CCRF-HSB-2(RCB0016)
TGBC11TKB(RCB1148) |
