RRC ID 39500
Author Suzuki M, Kase Y, Kanai T, Ando K.
Title Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines.
Journal Int. J. Radiat. Oncol. Biol. Phys.
Abstract PURPOSE:To investigate the change in the surviving fractions by fractionated-dose irradiations with carbon ions, based on the recovery of potentially lethal damage (PLDR) and the change of radiosensitivity by every fractionated-dose irradiation.
METHODS AND MATERIALS:One normal human and four human-tumor cell lines were used. Cells were irradiated with carbon ions accelerated by the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences in Japan. The LET values were estimated to be 13.18 keV/microm for low-LET beams and 76.92 +/- 0.20 keV/microm for high-LET beams. Fractionated-dose irradiations were carried out with 5 fractions within a 24-h interval.
RESULTS:The surviving fractions for the fractionated-dose irradiation with X-rays and carbon ions decreased exponentially with increasing the number of fractions in the tumor cell lines. In contrast, the surviving fractions for the carbon ions in normal human cells decreased exponentially as well as the tumor cell lines, while it tended to level off from the 3rd to the 5th fraction in the case of using X-rays.
CONCLUSION:The change in both the recovery ratio of the PLDR and radiosensitivity by every fractionated-dose irradiation depends on individual cell lines and the quality of radiations.
Volume 48(1)
Pages 251-8
Published 2000-8-1
DOI 10.1016/s0360-3016(00)00606-4
PII S0360-3016(00)00606-4
PMID 10924996
MeSH Carbon / therapeutic use* Cell Survival / physiology Cell Survival / radiation effects* Dose Fractionation, Radiation* Dose-Response Relationship, Radiation Fibroblasts / physiology Fibroblasts / radiation effects Heavy Ion Radiotherapy* Humans Linear Energy Transfer* Radiation Tolerance / physiology* Radiobiology Tumor Cells, Cultured / physiology Tumor Cells, Cultured / radiation effects Tumor Stem Cell Assay
IF 6.203
Times Cited 18
Human and Animal Cells