論文 - 詳細
| RRC ID | 39520 |
|---|---|
| 著者 | Taira M, Nakao H, Matsumoto T, Takahashi J. |
| タイトル | Cytotoxic effect of methyl methacrylate on 4 cultured fibroblasts. |
| ジャーナル | Int J Prosthodont |
| Abstract |
PURPOSE:The objective of this study was to examine the cytotoxic effect of methyl methacrylate (MMA) monomer on 4 mammalian fibroblasts. MATERIALS AND METHODS:Four cells--C3H10T1/2, L929, Balb/3T3 clone A31, and MC3T3-E1--were incubated for 6 days in 24-well microplates filled with 1 mL of Dulbecco's Modified Eagle medium containing MMA monomer that ranged from 0 to 200 mM/L. Cytotoxicity was evaluated by direct cell number count. RESULTS:L929 possessed the largest TC50 value (the amount of MMA that caused 50% cell death) (34 mM/L), and Balb/3T3 clone A31 had the least value (1 mM/L); C3H10T1/2 and MC3T3-E1 had intermediate values (25 mM/L and 16 mM/L, respectively). CONCLUSION:This study showed that the MMA monomer had dose-dependent cytotoxicity, which varied among the cells tested. |
| 巻・号 | 13(4) |
| ページ | 311-5 |
| 公開日 | 2000-1-1 |
| PMID | 11203647 |
| MeSH | 3T3 Cells / drug effects Animals Cell Count Dose-Response Relationship, Drug Fibroblasts / drug effects* L Cells / drug effects Lethal Dose 50 Methylmethacrylate / toxicity* Mice Mice, Inbred BALB C Mice, Inbred C3H |
| IF | 1.49 |
| 引用数 | 20 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| リソース情報 | |
| ヒト・動物細胞 | L929 BALB/3T3 clone A31(RCB0005) MC3T3-E1(RCB1126) |