論文 - 詳細
| RRC ID | 39528 |
|---|---|
| 著者 | Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H. |
| タイトル | Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
In our previous paper, we have reported that niacin-related compounds, particularly picolinic acid, dipicolinic acid, and isonicotinamide, induced apoptosis in HL-60 cells but that niacin did not. Moreover, picolinamide, N1-methylnicotinamide, 6-aminonicotinamide, quinolinic acid, and cinchomeronic acid also had the function of DNA fragmentation in HL-60 cells analyzed by flow cytometry, the ratio of DNA fragmentation finally being about 40% after treatment with these compounds at 10 mM for 24 h. In this study, we found that these compounds also induced apoptosis in HL-60 cells. The wide-spectrum caspase inhibitors prevented DNA fragmentation induced by these compounds. Interestingly, 6-aminonicotinamide induced apoptosis at a comparatively low concentration, while picolinic acid, dipicolinic acid, and isonicotinamide did not at 1 mM. Our results suggest that both NAD metabolism and NAD biosynthesis may be related to the process of apoptosis induced by niacin-related compounds. |
| 巻・号 | 64(2) |
| ページ | 327-32 |
| 公開日 | 2000-2-1 |
| DOI | 10.1271/bbb.64.327 |
| PMID | 10737189 |
| MeSH | Apoptosis / drug effects* Electrophoresis, Agar Gel Flow Cytometry HL-60 Cells Humans Niacinamide / analogs & derivatives Niacinamide / pharmacology* Quinolinic Acid / pharmacology* |
| IF | 1.516 |
| 引用数 | 28 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |