Reference - Detail
| RRC ID | 39530 |
|---|---|
| Author | Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H. |
| Title | Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes. |
| Volume | 64(5) |
| Pages | 1075-8 |
| Published | 2000-5-1 |
| DOI | 10.1271/bbb.64.1075 |
| PMID | 10879486 |
| MeSH | Apoptosis / drug effects Apoptosis / physiology* Caffeic Acids / pharmacology Caspase Inhibitors Cell Size Citrus / chemistry* DNA Fragmentation / drug effects Dose-Response Relationship, Drug Electrophoresis, Agar Gel Flavanones* Flavonoids / chemistry Flavonoids / metabolism* Flavonoids / pharmacology* HL-60 Cells Hesperidin / analogs & derivatives* Hesperidin / pharmacology Humans Phloroglucinol / pharmacology |
| IF | 1.516 |
| Times Cited | 30 |
| WOS Category | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
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| The most frequently cited source | |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |