論文 - 詳細
| RRC ID | 39596 |
|---|---|
| 著者 | Mori M, Sakata I, Hirano T, Obana A, Nakajima S, Hikida M, Kumagai T. |
| タイトル | Photodynamic therapy for experimental tumors using ATX-S10(Na), a hydrophilic chlorin photosensitizer, and diode laser. |
| ジャーナル | Jpn J Cancer Res |
| Abstract |
ATX-S10(Na), a hydrophilic chlorin photosensitizer having an absorption maximum at 670 nm, is a candidate second-generation photosensitizer for use in photodynamic therapy (PDT) for cancer treatment. The effectiveness of PDT using ATX-S10(Na) and a diode laser for experimental tumors was evaluated in vitro and in vivo. In-vitro PDT using ATX-S10(Na) and the diode laser showed drug concentration-, laser dose- and drug exposure time-dependent cytotoxicity to various human and mouse tumor cell lines. In Meth-A sarcoma-implanted mice, optimal PDT conditions were found where tumors were completely eliminated without any toxicity. Against human tumor xenografts in nude mice, the combined use of 5 mg / kg ATX-S10(Na) and 200 J / cm(2) laser irradiation 3 h after ATX-S10(Na) administration showed excellent anti-tumor activity, and its efficacy was almost the same as that of PDT using 20 mg / kg porfimer sodium and a 100 J / cm(2) excimer dye laser 48 h after porfimer sodium injection. Microscopic observation of tumor tissues revealed that PDT using ATX-S10(Na) and the diode laser induced congestion, thrombus and degeneration of endothelial cells in tumor vessels, indicating that a vascular shutdown effect plays an important role in the anti-tumor activity of PDT using ATX-S10(Na) and the diode laser. |
| 巻・号 | 91(7) |
| ページ | 753-9 |
| 公開日 | 2000-7-1 |
| DOI | 10.1111/j.1349-7006.2000.tb01009.x |
| PMID | 10920284 |
| PMC | PMC5926412 |
| MeSH | Animals Antineoplastic Agents / pharmacology* Dihematoporphyrin Ether / pharmacology HeLa Cells / drug effects Humans KB Cells / drug effects Lasers Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplasms, Experimental / drug therapy* Neoplasms, Experimental / pathology Photochemotherapy / methods* Photosensitizing Agents / pharmacology* Porphyrins / pharmacology* Sarcoma, Experimental / drug therapy Sarcoma, Experimental / pathology Transplantation, Heterologous |
| 引用数 | 26 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |