Reference - Detail
| RRC ID | 39610 |
|---|---|
| Author | Kataoka H, Itoh H, Uchino H, Hamasuna R, Kitamura N, Nabeshima K, Koono M. |
| Title | Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas. |
| Journal | Cancer Lett |
| Abstract |
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) was recently identified as a potent inhibitor of hepatocyte growth factor activator. It was also independently reported as placental bikunin (PB) and as a protein over-expressed in pancreatic cancer. The expression of HAI-2/PB was analyzed in human normal colon mucosa, adenomas, and carcinomas. HAI-2/PB mRNA was consistently expressed in the colorectal mucosa. The expression was conserved in the neoplastic colorectal mucosa, and no relationship was found between HAI-2/PB mRNA levels and tumor stages. Moreover, 13 out of 14 colorectal carcinoma cell lines expressed HAI-2/PB mRNA. Immunohistochemically, HAI-2/PB proteins were predominantly stained beneath the apical surface of normal enterocytes. In tumor tissues, rather disarranged intracytoplasmic granular staining was observed. The HAI-2/PB immunoreactivity was well conserved in the colonic adenoma-carcinoma sequence, and this protein may have important unknown function in the intestinal mucosa. |
| Volume | 148(2) |
| Pages | 127-34 |
| Published | 2000-2-1 |
| DOI | 10.1016/s0304-3835(99)00322-5 |
| PII | S0304383599003225 |
| PMID | 10695988 |
| MeSH | Adult Aged Aged, 80 and over Animals Cell Differentiation Colon / metabolism Colorectal Neoplasms / genetics Colorectal Neoplasms / metabolism* Colorectal Neoplasms / pathology Female Glycoproteins / biosynthesis* Glycoproteins / genetics Humans Intestinal Mucosa / metabolism Male Membrane Glycoproteins / biosynthesis* Membrane Glycoproteins / genetics Mice Mice, Inbred BALB C Middle Aged RNA, Messenger / biosynthesis Serine Proteinase Inhibitors / biosynthesis* Serine Proteinase Inhibitors / genetics Trypsin Inhibitor, Kunitz Soybean* |
| IF | 7.36 |
| Times Cited | 23 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | CW-2(RCB0778) |