論文 - 詳細
| RRC ID | 39616 |
|---|---|
| 著者 | Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M. |
| タイトル | MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. |
| ジャーナル | FEBS Lett |
| Abstract |
We have identified and characterized a novel member of the ankyrin-repeat family named 'molecule possessing ankyrin-repeats induced by lipopolysaccharide' (MAIL). The C-terminal portion of MAIL shared high sequence homology with the I kappa B family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (<0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells. These findings indicate that MAIL is one of the nuclear I kappa B proteins and an activator of IL-6 production. |
| 巻・号 | 485(1) |
| ページ | 53-6 |
| 公開日 | 2000-11-17 |
| DOI | 10.1016/s0014-5793(00)02185-2 |
| PII | S0014-5793(00)02185-2 |
| PMID | 11086164 |
| MeSH | 3T3 Cells Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Cell Nucleus / chemistry Cloning, Molecular DNA, Complementary / genetics Drug Synergism Gene Expression Green Fluorescent Proteins Interleukin-6 / biosynthesis* Lipopolysaccharides / pharmacology* Luminescent Proteins / genetics Male Mice Mice, Inbred C57BL Molecular Sequence Data Nuclear Proteins / chemistry Nuclear Proteins / genetics Nuclear Proteins / pharmacology* Organ Specificity RNA, Messenger / analysis Recombinant Fusion Proteins Sequence Homology Transfection |
| IF | 3.057 |
| 引用数 | 108 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 3T3 Swiss Albino(RCB1642) |
| 遺伝子材料 | pDEST12.2-MAILL (RDB03013) pDEST12.2-MAILS (RDB03014) |