| RRC ID |
39616
|
| 著者 |
Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M.
|
| タイトル |
MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
We have identified and characterized a novel member of the ankyrin-repeat family named 'molecule possessing ankyrin-repeats induced by lipopolysaccharide' (MAIL). The C-terminal portion of MAIL shared high sequence homology with the I kappa B family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (<0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells. These findings indicate that MAIL is one of the nuclear I kappa B proteins and an activator of IL-6 production.
|
| 巻・号 |
485(1)
|
| ページ |
53-6
|
| 公開日 |
2000-11-17
|
| DOI |
10.1016/s0014-5793(00)02185-2
|
| PII |
S0014-5793(00)02185-2
|
| PMID |
11086164
|
| MeSH |
3T3 Cells
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
Cell Nucleus / chemistry
Cloning, Molecular
DNA, Complementary / genetics
Drug Synergism
Gene Expression
Green Fluorescent Proteins
Interleukin-6 / biosynthesis*
Lipopolysaccharides / pharmacology*
Luminescent Proteins / genetics
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Nuclear Proteins / chemistry
Nuclear Proteins / genetics
Nuclear Proteins / pharmacology*
Organ Specificity
RNA, Messenger / analysis
Recombinant Fusion Proteins
Sequence Homology
Transfection
|
| IF |
3.057
|
| 引用数 |
108
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
3T3 Swiss Albino(RCB1642) |
| 遺伝子材料 |
pDEST12.2-MAILL (RDB03013)
pDEST12.2-MAILS (RDB03014) |
