| RRC ID |
39643
|
| Author |
Hamada T, Ui-Tei K, Miyata Y.
|
| Title |
A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family.
|
| Journal |
FEBS Lett
|
| Abstract |
We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.
|
| Volume |
475(2)
|
| Pages |
97-102
|
| Published |
2000-6-16
|
| DOI |
10.1016/s0014-5793(00)01640-9
|
| PII |
S0014-5793(00)01640-9
|
| PMID |
10858496
|
| MeSH |
Amino Acid Sequence
Animals
Blotting, Northern
CHO Cells
Cell Survival / drug effects
Chick Embryo
Cloning, Molecular
Cricetinae
DNA, Complementary / metabolism
Endothelial Growth Factors / genetics
Humans
Lymphokines / biosynthesis
Lymphokines / chemistry
Lymphokines / genetics*
Microscopy, Phase-Contrast
Molecular Sequence Data
Multigene Family
Platelet-Derived Growth Factor / biosynthesis
Platelet-Derived Growth Factor / chemistry
Platelet-Derived Growth Factor / genetics*
Protein Structure, Tertiary
RNA, Messenger / metabolism
Sequence Homology, Amino Acid
Spinal Cord / embryology
Spinal Cord / metabolism*
Time Factors
Transfection
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
|
| IF |
3.057
|
| Times Cited |
18
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
CHO-K1(RCB0285)
10T1/2(RCB0247) |
