Reference - Detail
RRC ID | 39845 |
---|---|
Author | Goto S, Lin YC, Lai CY, Lee CM, Pan TL, Lord R, Chiang KC, Tseng HP, Lin CL, Cheng YF, Yokoyama H, Kitano S, Chen CL. |
Title | Telomerase activity in rat liver allografts. |
Journal | Transplantation |
Abstract |
BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. RESULTS:At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA-PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. CONCLUSION:These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance. |
Volume | 69(5) |
Pages | 1013-5 |
Published | 2000-3-15 |
DOI | 10.1097/00007890-200003150-00062 |
PMID | 10755570 |
MeSH | Animals Graft Rejection / enzymology Liver / enzymology* Liver Transplantation* Rats Rats, Inbred Strains Telomerase / metabolism* Transplantation, Homologous Transplantation, Isogeneic |
IF | 4.546 |
Times Cited | 5 |
WOS Category | TRANSPLANTATION SURGERY IMMUNOLOGY |
Resource | |
Human and Animal Cells |