論文 - 詳細
| RRC ID | 39915 |
|---|---|
| 著者 | Shibaki T, Suzutani T, Yoshida I, Ogasawara M, Azuma M. |
| タイトル | Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type 1. |
| ジャーナル | J Interferon Cytokine Res |
| Abstract |
We isolated a UL13 gene-deleted mutant of the herpes simplex virus type 1 (HSV-1) strain VR3 (VRDelta13) and its revertant virus (VRDelta13R). This deletion mutant still had virus host shutoff (vhs) activity, although a previous report had suggested the possibility of a functional relation between the UL13 product, that is protein kinase (PK), and vhs activity. We compared the in vivo growth of these viruses in BALB/c mice. VRDelta13 was cleared in the early period of intraperitoneal infection. VRDelta13 had a higher sensitivity to the mouse type I interferon (IFN) and showed a higher level of IFN induction in the study period of infection than did VR3 and VRDelta13R. These results suggest that a nonspecific antiviral response (i.e., the IFN system) may contribute to this rapid inhibition of viral replication in vivo. |
| 巻・号 | 21(5) |
| ページ | 279-85 |
| 公開日 | 2001-5-1 |
| DOI | 10.1089/107999001300177466 |
| PMID | 11429158 |
| MeSH | 3T3 Cells Animals Cell Line Chlorocebus aethiops Disease Models, Animal Drug Resistance / immunology Female Gene Deletion* Genes, Viral / genetics* Herpes Simplex / immunology* Herpes Simplex / mortality Herpes Simplex / virology* Herpesvirus 1, Human / enzymology Herpesvirus 1, Human / genetics* Herpesvirus 1, Human / isolation & purification Herpesvirus 1, Human / pathogenicity* Humans Interferon Type I / biosynthesis Interferon Type I / physiology* Lethal Dose 50 Mice Mice, Inbred BALB C Protein Kinases / genetics* Substrate Specificity / genetics Vero Cells Viral Plaque Assay Viral Structural Proteins / genetics* Virulence Virus Replication / genetics |
| IF | 2.032 |
| 引用数 | 22 |
| WOS 分野 | IMMUNOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |