| RRC ID |
39915
|
| 著者 |
Shibaki T, Suzutani T, Yoshida I, Ogasawara M, Azuma M.
|
| タイトル |
Participation of type I interferon in the decreased virulence of the UL13 gene-deleted mutant of herpes simplex virus type 1.
|
| ジャーナル |
J Interferon Cytokine Res
|
| Abstract |
We isolated a UL13 gene-deleted mutant of the herpes simplex virus type 1 (HSV-1) strain VR3 (VRDelta13) and its revertant virus (VRDelta13R). This deletion mutant still had virus host shutoff (vhs) activity, although a previous report had suggested the possibility of a functional relation between the UL13 product, that is protein kinase (PK), and vhs activity. We compared the in vivo growth of these viruses in BALB/c mice. VRDelta13 was cleared in the early period of intraperitoneal infection. VRDelta13 had a higher sensitivity to the mouse type I interferon (IFN) and showed a higher level of IFN induction in the study period of infection than did VR3 and VRDelta13R. These results suggest that a nonspecific antiviral response (i.e., the IFN system) may contribute to this rapid inhibition of viral replication in vivo.
|
| 巻・号 |
21(5)
|
| ページ |
279-85
|
| 公開日 |
2001-5-1
|
| DOI |
10.1089/107999001300177466
|
| PMID |
11429158
|
| MeSH |
3T3 Cells
Animals
Cell Line
Chlorocebus aethiops
Disease Models, Animal
Drug Resistance / immunology
Female
Gene Deletion*
Genes, Viral / genetics*
Herpes Simplex / immunology*
Herpes Simplex / mortality
Herpes Simplex / virology*
Herpesvirus 1, Human / enzymology
Herpesvirus 1, Human / genetics*
Herpesvirus 1, Human / isolation & purification
Herpesvirus 1, Human / pathogenicity*
Humans
Interferon Type I / biosynthesis
Interferon Type I / physiology*
Lethal Dose 50
Mice
Mice, Inbred BALB C
Protein Kinases / genetics*
Substrate Specificity / genetics
Vero Cells
Viral Plaque Assay
Viral Structural Proteins / genetics*
Virulence
Virus Replication / genetics
|
| IF |
2.032
|
| 引用数 |
22
|
|
WOS 分野
|
IMMUNOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
J774.1(RCB0434) |
