Reference - Detail
| RRC ID | 39918 |
|---|---|
| Author | Ogata S, Inoue K, Iwata K, Okumura K, Taguchi H. |
| Title | Apoptosis induced by picolinic acid-related compounds in HL-60 cells. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis. |
| Volume | 65(10) |
| Pages | 2337-9 |
| Published | 2001-10-1 |
| DOI | 10.1271/bbb.65.2337 |
| PMID | 11758936 |
| MeSH | Apoptosis / drug effects* DNA Fragmentation Flow Cytometry Fusaric Acid / pharmacology HL-60 Cells / drug effects* Humans Picolinic Acids / pharmacology* |
| IF | 1.516 |
| Times Cited | 22 |
| WOS Category | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | |