論文 - 詳細
| RRC ID | 39944 |
|---|---|
| 著者 | Yamamoto Y, Nakajima M, Yamazaki H, Yokoi T. |
| タイトル | Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells. |
| ジャーナル | Life Sci |
| Abstract |
Troglitazone is an antidiabetic agent that increases the insulin sensitivity of target tissues in non-insulin-dependent diabetes mellitus. It has been reported that troglitazone causes severe hepatic injury in certain individuals. In the present study, the mechanism for the hepatic injury by troglitazone was investigated with human hepatoma cell lines. HepG2 cells were incubated with troglitazone, its metabolites M-1 (sulfate), M-2 (gulucronide), M-3 (quinone), and other thiazolidinediones (pioglitazone and rosiglitazone). Troglitazone exhibited time- and concentration-dependent cytotoxicity and M-3 also exhibited weak cytotoxicity. Troglitazone induced apoptotic cell death characterized by internucleosomal DNA fragmentation and nuclear condensation. As other thiazolidinediones, pioglitazone and rosiglitazone, did not induce cell death and apoptosis in the present study, the affinity to PPARgamma may not affect the induction of apoptosis by troglitazone. These results suggest that troglitazone induces apoptotic hepatocyte death which it may be one of the factors of liver injury in humans. |
| 巻・号 | 70(4) |
| ページ | 471-82 |
| 公開日 | 2001-12-14 |
| DOI | 10.1016/s0024-3205(01)01432-1 |
| PII | S0024-3205(01)01432-1 |
| PMID | 11798015 |
| MeSH | Apoptosis / drug effects* Carcinoma, Hepatocellular Cell Survival / drug effects Chromans / metabolism Chromans / toxicity* DNA Fragmentation Dose-Response Relationship, Drug Humans Hypoglycemic Agents / metabolism Hypoglycemic Agents / toxicity* Pioglitazone Rosiglitazone Tetrazolium Salts / metabolism Thiazoles / metabolism Thiazoles / toxicity* Thiazolidinediones* Troglitazone Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / metabolism Tumor Cells, Cultured / pathology |
| IF | 3.647 |
| 引用数 | 74 |
| WOS 分野 | PHARMACOLOGY & PHARMACY MEDICINE, RESEARCH & EXPERIMENTAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7(RCB1366) Hep G2(RCB0459) |