論文 - 詳細
| RRC ID | 40045 |
|---|---|
| 著者 | Narbonne-Reveau K, Lanet E, Dillard C, Foppolo S, Chen CH, Parrinello H, Rialle S, Sokol NS, Maurange C. |
| タイトル | Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila. |
| ジャーナル | Elife |
| Abstract |
Pediatric neural tumors are often initiated during early development and can undergo very rapid transformation. However, the molecular basis of this early malignant susceptibility remains unknown. During Drosophila development, neural stem cells (NSCs) divide asymmetrically and generate intermediate progenitors that rapidly differentiate in neurons. Upon gene inactivation, these progeny can dedifferentiate and generate malignant tumors. Here, we find that intermediate progenitors are prone to malignancy only when born during an early window of development while expressing the transcription factor Chinmo, and the mRNA-binding proteins Imp/IGF2BP and Lin-28. These genes compose an oncogenic module that is coopted upon dedifferentiation of early-born intermediate progenitors to drive unlimited tumor growth. In late larvae, temporal transcription factor progression in NSCs silences the module, thereby limiting mitotic potential and terminating the window of malignant susceptibility. Thus, this study identifies the gene regulatory network that confers malignant potential to neural tumors with early developmental origins. |
| 巻・号 | 5 |
| 公開日 | 2016-6-14 |
| DOI | 10.7554/eLife.13463 |
| PII | e13463 |
| PMID | 27296804 |
| PMC | PMC4907696 |
| MeSH | Animals Carcinogenesis* Cell Differentiation* Cell Proliferation* Disease Susceptibility* Drosophila / embryology* Drosophila Proteins / biosynthesis Nerve Tissue Proteins / biosynthesis Neural Stem Cells / physiology* RNA-Binding Proteins / biosynthesis Time Factors |
| IF | 7.08 |
| 引用数 | 30 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 42 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 17156R-1 |