| RRC ID |
40053
|
| Author |
Matsuyama M, Haneda C, Kato K.
|
| Title |
Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.
|
| Journal |
Nagoya J Med Sci
|
| Abstract |
The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
|
| Volume |
75(3-4)
|
| Pages |
251-4
|
| Published |
2013-8-1
|
| PMID |
24640181
|
| PMC |
PMC4345667
|
| MeSH |
Animals
Animals, Congenic*
Chromosome Mapping / methods*
Chromosomes / ultrastructure*
Crosses, Genetic
Disease Models, Animal
Female
Hydronephrosis / genetics
Kidney / abnormalities*
Kidney Diseases / genetics*
Male
Rats
Rats, Inbred ACI
Rats, Inbred BUF
Rats, Inbred WKY
Species Specificity
|
| IF |
0.762
|
| Times Cited |
0
|
|
WOS Category
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Rats |
BUF/Mna (strainID=458) |
