| RRC ID |
40056
|
| 著者 |
Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
|
| タイトル |
Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Some neurons have the ability to enhance output voltage to input current with a preferred frequency, which is called resonance. Resonance is thought to be a basis for membrane potential oscillation. Although ion channels responsible for resonance have been reported, the precise mechanisms by which these channels work remain poorly understood. We have found that resonance is reduced but clearly present in the inferior olivary neurons of Cav3.1 T-type voltage-dependent Ca(2+) channel knockout (KO) mice. The activation of Cav3.1 channels is strongly membrane potential dependent, but less frequency dependent. Residual resonance in Cav3.1 KO mice is abolished by a hyper-polarization-activated cyclic nucleotide-gated (HCN) channel blocker, ZD7288, and is partially suppressed by voltage-dependent K(+) channel blockers. Resonance is inhibited by ZD7288 in wild-type mice and impaired in HCN1 KO mice, suggesting that the HCN1 channel is essential for resonance. The ZD7288-sensitive current is nearly sinusoidal and strongly frequency dependent. These results suggest that Cav3.1 and HCN1 channels act as amplifying and resonating conductances, respectively.
|
| 巻・号 |
16(4)
|
| ページ |
994-1004
|
| 公開日 |
2016-7-26
|
| DOI |
10.1016/j.celrep.2016.06.053
|
| PII |
S2211-1247(16)30807-5
|
| PMID |
27425615
|
| MeSH |
Animals
Calcium Channels, T-Type / metabolism
Cerebellar Cortex / metabolism*
Cerebellar Cortex / physiology*
Cyclic Nucleotide-Gated Cation Channels / metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism
Membrane Potentials / physiology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons / metabolism
Neurons / physiology*
Potassium Channels / metabolism
|
| IF |
8.109
|
| 引用数 |
10
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC01465 |
