Reference - Detail
| RRC ID | 40083 |
|---|---|
| Author | Oya A, Tanaka N, Kusama T, Kim SY, Hayashi S, Kojoma M, Hishida A, Kawahara N, Sakai K, Gonoi T, Kobayashi J. |
| Title | Prenylated benzophenones from Triadenum japonicum. |
| Journal | J Nat Prod |
| Abstract |
Six new prenylated benzophenones, (-)-nemorosonol (1) and trijapins A-E (2-6), were isolated from the aerial parts of Triadenum japonicum. (-)-Nemorosonol (1) and trijapins A-C (2-4) have a common tricyclo[4.3.1.0(3,7)]decane skeleton, while 1 is an enantiomer of (+)-nemorosonol previously isolated from Clusia nemorosa. The absolute configuration of (-)-nemorosonol (1) was assigned by ECD spectroscopy. Trijapins A-C (2-4) are analogues of 1 possessing an additional tetrahydrofuran ring. Trijapins D (5) and E (6) are prenylated benzophenones with a 1,2-dioxane moiety and a hydroperoxy group, respectively. (-)-Nemorosonol (1) exhibited antimicrobial activity against Escherichia coli (MIC, 8 μg/mL), Staphylococcus aureus (MIC, 16 μg/mL), Bacillus subtilis (MIC, 16 μg/mL), Micrococcus luteus (MIC, 32 μg/mL), Aspergillus niger (IC50, 16 μg/mL), Trichophyton mentagrophytes (IC50, 8 μg/mL), and Candida albicans (IC50, 32 μg/mL), while trijapin D (5) showed antimicrobial activity against C. albicans (IC50, 8 μg/mL). |
| Volume | 78(2) |
| Pages | 258-64 |
| Published | 2015-2-27 |
| DOI | 10.1021/np500827h |
| PMID | 25602977 |
| MeSH | Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Aspergillus niger / drug effects Bacillus subtilis / drug effects Benzophenones / chemistry Benzophenones / isolation & purification* Benzophenones / pharmacology Candida albicans / drug effects Escherichia coli / drug effects Hypericum / chemistry* Japan Microbial Sensitivity Tests Micrococcus luteus / drug effects Molecular Structure Plant Components, Aerial / chemistry Prenylation Staphylococcus aureus / drug effects Stereoisomerism Trichophyton / drug effects |
| IF | 3.782 |
| Times Cited | 20 |
| WOS Category | PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | NA |