論文 - 詳細
| RRC ID | 4036 |
|---|---|
| 著者 | Xing DH, Lai ZB, Zheng ZY, Vinod KM, Fan BF, Chen ZX. |
| タイトル | Stress- and pathogen-induced Arabidopsis WRKY48 is a transcriptional activator that represses plant basal defense. |
| ジャーナル | Mol Plant |
| Abstract |
Plant WRKY transcription factors can function as either positive or negative regulators of plant basal disease resistance. Arabidopsis WRKY48 is induced by mechanical and/or osmotic stress due to infiltration and pathogen infection and, therefore, may play a role in plant defense responses. WRKY48 is localized to the nucleus, recognizes the TTGACC W-box sequence with a high affinity in vitro and functions in plant cells as a strong transcriptional activator. To determine the biological functions directly, we have isolated loss-of-function T-DNA insertion mutants and generated gain-of-function transgenic overexpression plants for WRKY48 in Arabidopsis. Growth of a virulent strain of the bacterial pathogen Pseudomonas syringae was decreased in the wrky48 T-DNA insertion mutants. The enhanced resistance of the loss-of-function mutants was associated with increased induction of salicylic acid-regulated PR1 by the bacterial pathogen. By contrast, transgenic WRKY48-overexpressing plants support enhanced growth of P. syringae and the enhanced susceptibility was associated with reduced expression of defense-related PR genes. These results suggest that WRKY48 is a negative regulator of PR gene expression and basal resistance to the bacterial pathogen P. syringae. |
| 巻・号 | 1(3) |
| ページ | 459-70 |
| 公開日 | 2008-5-1 |
| DOI | 10.1093/mp/ssn020 |
| PII | S1674-2052(14)60341-5 |
| PMID | 19825553 |
| MeSH | Amino Acid Sequence Arabidopsis / drug effects Arabidopsis / genetics Arabidopsis / metabolism* Arabidopsis Proteins / chemistry Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism* Base Sequence DNA Probes DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Gene Expression Regulation, Plant* Kinetics Molecular Sequence Data Molecular Weight Plant Diseases / microbiology* Plant Diseases / prevention & control Pseudomonas syringae / pathogenicity* RNA, Plant / chemistry RNA, Plant / genetics RNA, Ribosomal / chemistry RNA, Ribosomal / genetics Salicylic Acid / pharmacology Sequence Alignment Sequence Homology, Nucleic Acid Trans-Activators / genetics Trans-Activators / metabolism* Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 12.084 |
| 引用数 | 80 |
| WOS 分野 | PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | pda03899 |