Reference - Detail
| RRC ID | 40930 |
|---|---|
| Author | Aiba Y, Nakano Y, Koga Y, Takahashi K, Komatsu Y. |
| Title | A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice. |
| Journal | Microbiologyopen |
| Abstract |
A novel strain of Lactobacillus johnsonii No. 1088 was isolated from the gastric juice of a healthy Japanese male volunteer, and characterized for its effectiveness in the stomach environment. Lactobacillus johnsonii No. 1088 was found to have the strongest acid resistance among several lactobacilli examined (>10% of cells survived at pH 1.0 after 2 h), and such a high acid resistance property was a specific characteristic of this strain of L. johnsonii. When cultured with various virulent bacteria, L. johnsonii No. 1088 inhibited the growth of Helicobacter pylori, Escherichia coli O-157, Salmonella Typhimurium, and Clostridium difficile, in which case its effectiveness was more potent than that of a type strain of L. johnsonii, JCM2012. In addition to its effect in vitro, L. johnsonii No. 1088 inhibited the growth of H. pylori in human intestinal microbiota-associated mice in both its live and lyophilized forms. Moreover, L. johnsonii No. 1088 suppressed gastric acid secretion in mice via decreasing the number of gastrin-positive cells in the stomach. These results taken together suggest that L. johnsonii No. 1088 is a unique lactobacillus having properties beneficial for supporting H. pylori eradication by triple therapy including the use of a proton pump inhibitor (PPI) and also for prophylaxis of gastroesophageal reflux disease possibly caused after H. pylori eradication as a side effect of PPI. |
| Volume | 4(3) |
| Pages | 465-74 |
| Published | 2015-6-1 |
| DOI | 10.1002/mbo3.252 |
| PMID | 25771812 |
| PMC | PMC4475388 |
| MeSH | Animals Antibiosis* Disease Models, Animal Gastric Acid / metabolism* Gastrins / blood Gastrins / metabolism* Gastrointestinal Microbiome Helicobacter Infections / metabolism Helicobacter Infections / microbiology Helicobacter pylori / physiology* Humans Lactobacillus / isolation & purification Lactobacillus / physiology* Mice Proton Pump Inhibitors / pharmacology |
| IF | 3.142 |
| Times Cited | 17 |
| WOS Category | MICROBIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 2012 JCM 1131 JCM 1296 |