論文 - 詳細
| RRC ID | 41378 |
|---|---|
| 著者 | Sagawa Y, Nishi H, Isaka K, Fujito A, Takayama M. |
| タイトル | The correlation of TERT expression with c-myc expression in cervical cancer. |
| ジャーナル | Cancer Lett |
| Abstract |
Recently putative catalytic telomerase subunit was identified as telomerase reverse transcriptase (TERT). Several reports showed that TERT expression correlated with telomerase activity. It has also been found that c-myc can induce telomerase activation through TERT expression. We examined expression of TERT and c-myc and their correlation in cervical cancers by reverse transcription-polymerase chain reaction (RT-PCR). It was found that TERT and c-myc expression was observed mostly in malignancies and expression of c-myc was concordant for positivity and negativity with TERT. These results support recent studies that c-myc expression is closely associated with TERT and telomerase activity. c-myc up-regulation may play an important role in activation of TERT and telomerase. |
| 巻・号 | 168(1) |
| ページ | 45-50 |
| 公開日 | 2001-7-10 |
| DOI | 10.1016/s0304-3835(01)00501-8 |
| PII | S0304383501005018 |
| PMID | 11368876 |
| MeSH | Cervix Uteri / metabolism DNA-Binding Proteins Female HeLa Cells Humans Polymerase Chain Reaction Proto-Oncogene Proteins c-myc / biosynthesis* RNA* RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Telomerase / biosynthesis* Telomerase / metabolism Tumor Cells, Cultured Uterine Cervical Neoplasms / metabolism* Uterine Cervical Neoplasms / pathology |
| IF | 7.36 |
| 引用数 | 37 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | TCS(RCB0638) TCO-1(RCB0640) OMC-1(RCB0753) |