| RRC ID |
41428
|
| Author |
Min BS, Gao JJ, Nakamura N, Kim YH, Hattori M.
|
| Title |
Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.
|
| Volume |
49(9)
|
| Pages |
1217-9
|
| Published |
2001-9-1
|
| DOI |
10.1248/cpb.49.1217
|
| PMID |
11558618
|
| MeSH |
Alkaloids / chemistry*
Alkaloids / pharmacology*
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Chromatography, Liquid
Female
Indicators and Reagents
Japan
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Neoplasm Transplantation
Neoplasms, Experimental / drug therapy
Phenanthrenes / chemistry
Phenanthrenes / pharmacology*
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured
|
| IF |
1.416
|
| Times Cited |
35
|
|
WOS Category
|
CHEMISTRY, MULTIDISCIPLINARY
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
Meth-A(RCB0464)
LLC(RCB0558) |
