| RRC ID |
41482
|
| Author |
Tokunaka K, Ohno N, Adachi Y, Miura NN, Yadomae T.
|
| Title |
Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice.
|
| Journal |
Int Immunopharmacol
|
| Abstract |
This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/c mice to CDF1 mice led to further suppression of tumor growth as well as P815-immunized spleen cells. Third, CSBG enhanced antitumor immunity in gene therapy using B7-1-transfected P815 cells. These results strongly suggest that CSBG enhances the host defense response to tumor due in part to an adjuvant effect.
|
| Volume |
2(1)
|
| Pages |
59-67
|
| Published |
2002-1-1
|
| DOI |
10.1016/s1567-5769(01)00148-5
|
| PII |
S1567-5769(01)00148-5
|
| PMID |
11789670
|
| MeSH |
Animals
B7-1 Antigen / genetics
Candida / chemistry*
Cell Wall / chemistry*
Combined Modality Therapy
Female
Flow Cytometry
Genetic Therapy*
Glucans / chemistry
Glucans / therapeutic use*
Immunotherapy, Adoptive*
Indicators and Reagents
Mammary Neoplasms, Experimental / pathology
Mammary Neoplasms, Experimental / therapy*
Mast-Cell Sarcoma / pathology
Mast-Cell Sarcoma / therapy*
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Neoplasm Transplantation
Plasmids / genetics
Survival Analysis
Transfection
Tumor Cells, Cultured
|
| IF |
3.943
|
| Times Cited |
26
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
IMMUNOLOGY
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
