Reference - Detail
| RRC ID | 41482 |
|---|---|
| Author | Tokunaka K, Ohno N, Adachi Y, Miura NN, Yadomae T. |
| Title | Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice. |
| Journal | Int Immunopharmacol |
| Abstract |
This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/c mice to CDF1 mice led to further suppression of tumor growth as well as P815-immunized spleen cells. Third, CSBG enhanced antitumor immunity in gene therapy using B7-1-transfected P815 cells. These results strongly suggest that CSBG enhances the host defense response to tumor due in part to an adjuvant effect. |
| Volume | 2(1) |
| Pages | 59-67 |
| Published | 2002-1-1 |
| DOI | 10.1016/s1567-5769(01)00148-5 |
| PII | S1567-5769(01)00148-5 |
| PMID | 11789670 |
| MeSH | Animals B7-1 Antigen / genetics Candida / chemistry* Cell Wall / chemistry* Combined Modality Therapy Female Flow Cytometry Genetic Therapy* Glucans / chemistry Glucans / therapeutic use* Immunotherapy, Adoptive* Indicators and Reagents Mammary Neoplasms, Experimental / pathology Mammary Neoplasms, Experimental / therapy* Mast-Cell Sarcoma / pathology Mast-Cell Sarcoma / therapy* Mice Mice, Inbred BALB C Mice, Inbred DBA Neoplasm Transplantation Plasmids / genetics Survival Analysis Transfection Tumor Cells, Cultured |
| IF | 3.943 |
| Times Cited | 26 |
| WOS Category | PHARMACOLOGY & PHARMACY IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |