| RRC ID |
41491
|
| Author |
Nagayama M, Haga H, Kawabata K.
|
| Title |
Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
|
| Journal |
Cell Motil Cytoskeleton
|
| Abstract |
Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed.
|
| Volume |
50(4)
|
| Pages |
173-9
|
| Published |
2001-12-1
|
| DOI |
10.1002/cm.10008
|
| PII |
10.1002/cm.10008
|
| PMID |
11807938
|
| MeSH |
3T3 Cells
Animals
Cell Movement / physiology*
Elasticity
Fibroblasts / physiology*
Mice
Microscopy, Scanning Probe
Models, Biological
Stress Fibers / physiology
|
| Times Cited |
59
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
NIH3T3 |
