| RRC ID |
41499
|
| Author |
Wang LQ, Min BS, Li Y, Nakamura N, Qin GW, Li CJ, Hattori M.
|
| Title |
Annonaceous acetogenins from the leaves of Annona montana.
|
| Journal |
Bioorg Med Chem
|
| Abstract |
A novel Annonaceous acetogenin, montanacin F, with a new type of terminal lactone unit, was isolated from the leaves of Annona montana. Its structure was determined on the basis of spectral evidences and chemical methods, and a possible biosynthetic pathway was discussed. In addition, the cytotoxicity of montanacin F was evaluated in vitro against Lewis lung carcinoma (LLC) tumor cell lines. Furthermore, the previously isolated cytotoxic acetogenin annonacin against LLC was examined for in vivo antitumor activity with LLC tumor cells.
|
| Volume |
10(3)
|
| Pages |
561-5
|
| Published |
2002-3-1
|
| DOI |
10.1016/s0968-0896(01)00303-0
|
| PII |
S0968089601003030
|
| PMID |
11814843
|
| MeSH |
Animals
Annonaceae / chemistry*
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Carcinoma, Lewis Lung / drug therapy
Female
Furans / chemistry*
Furans / isolation & purification
Furans / pharmacology
Injections, Intraperitoneal
Lactones / chemistry*
Lactones / isolation & purification
Lactones / pharmacology
Mice
Plant Leaves / chemistry
Tumor Cells, Cultured / transplantation
|
| IF |
3.073
|
| Times Cited |
21
|
|
WOS Category
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
