論文 - 詳細
| RRC ID | 41513 |
|---|---|
| 著者 | Saitoh M, Taguchi K, Momose K, Suga K, Yamazaki N, Ono C, Suzuki T, Takeuchi O, Yasuda S, Miyata K. |
| タイトル | Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells. |
| ジャーナル | Cancer Chemother Pharmacol |
| Abstract |
PURPOSE:Interleukin-11 (IL-11) is a stromal cell derived multifunctional cytokine, which plays important roles in the hematopoietic and nonhematopoietic systems. Recombinant human IL-11 (rhIL-11) is used in the treatment of chemotherapy-induced thrombocytopenia. We have investigated the effects of rhIL-11 on the antitumor activity of chemotherapeutic agents and on thrombocytopenia in myelosuppressed mice bearing tumor cells. METHODS:We tested the effect of rhIL-11 on Lewis lung carcinoma (LLC) cell proliferation when used alone or in combination with three antitumor agents in vitro. Also, a newly developed chemotherapy-induced myelosuppressed mice model bearing LLC cells was used to study the effects of rhIL-11 on the antitumor activity and on thrombocytopenia. RESULTS:On its own, rhIL-11 (1-100 ng/ml) did not stimulate cell proliferation, and did not alter the antitumor activities of carboplatin, mitomycin C, or etoposide in vitro. In mice implanted with LLC cells (1 x 10(4)), carboplatin (50 mg/kg/day for 2 consecutive days, i.p.) inhibited tumor growth and caused thrombocytopenia. Treatment with rhIL-11 (500 microg/kg/day, from the day following the last dosing with carboplatin for 14 days, s.c.) successfully prevented thrombocytopenia without affecting the antitumor activity of carboplatin. With rhIL-11 there was no obvious effect on the red blood cell count, white blood cell count, or body weight. CONCLUSION:These results support the assertion that rhIL-11 may be a significant therapeutic agent for thrombocytopenia following cancer chemotherapy, and that it need be associated with little fear of tumor proliferation. |
| 巻・号 | 49(2) |
| ページ | 161-6 |
| 公開日 | 2002-2-1 |
| DOI | 10.1007/s00280-001-0387-1 |
| PMID | 11862431 |
| MeSH | Animals Antineoplastic Agents / adverse effects* Bone Marrow / drug effects Carboplatin / adverse effects* Carcinoma, Lewis Lung / blood Carcinoma, Lewis Lung / drug therapy* Interleukin-11 / therapeutic use* Mice Recombinant Proteins / therapeutic use Thrombocytopenia / chemically induced Thrombocytopenia / prevention & control* Tumor Cells, Cultured |
| IF | 2.967 |
| 引用数 | 4 |
| WOS 分野 | PHARMACOLOGY & PHARMACY ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |