Reference - Detail
| RRC ID | 41546 |
|---|---|
| Author | Maeda K, Takahashi K, Takahashi F, Tamura N, Maeda M, Kon S, Uede T, Fukuchi Y. |
| Title | Distinct roles of osteopontin fragments in the development of the pulmonary involvement in sarcoidosis. |
| Journal | Lung |
| Abstract |
Osteopontin (OPN) is a secreted glycoprotein with cell adhesive and chemoattractive functions and is expressed in granulomas of sarcoidosis. It is well documented that full-length OPN (F-OPN) is susceptible to proteolytic fragmentation resulting in carboxyl-terminal OPN (C-OPN). We have previously revealed that C-OPN suppresses cell adhesion mediated by F-OPN. However, the implication of F-OPN and C-OPN in the progression of pulmonary involvement in sarcoidosis has not yet been elucidated. In this study, we demonstrated that (l) OPN was expressed in granulomas of sarcoidosis, (2) plasma F-OPN level in patients with sarcoidosis, especially in stage II patients, was significantly elevated compared with those of the controls, (3) plasma C-OPN levels in patients of stages 0, I, and III were significantly higher than those of the controls, and (4) in vitro recombinant F-OPN induces macrophage migration and that C-OPN inhibits cell migration mediated by F-OPN. These results suggest that F-OPN may promote granuloma formation in sarcoidosis, while C-OPN may suppress it. Thus, OPN and its fragment may play distinct roles in the development of sarcoidosis. |
| Volume | 179(5) |
| Pages | 279-91 |
| Published | 2001-1-1 |
| DOI | 10.1007/s004080000068 |
| PMID | 11976896 |
| MeSH | Case-Control Studies Cell Adhesion Female Humans Lung / metabolism Lymph Nodes / metabolism Male Middle Aged Osteopontin Sarcoidosis, Pulmonary / etiology* Sialoglycoproteins / blood Sialoglycoproteins / chemistry Sialoglycoproteins / physiology* |
| IF | 1.817 |
| Times Cited | 22 |
| WOS Category | RESPIRATORY SYSTEM |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |