| RRC ID |
41582
|
| 著者 |
Morita H, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
|
| タイトル |
Adhesion of lactic acid bacteria to caco-2 cells and their effect on cytokine secretion.
|
| ジャーナル |
Microbiol Immunol
|
| Abstract |
Cytokines secreted by human enterocytes play a critical role in mucosal and systemic immunity. Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco-2 cells and their potential to stimulate proinflammatory cytokine secretion by this cell line. The bacteria adhered in a strain-dependent manner to Caco-2 cells. Contact with lactobacilli did not result in the production of IL-6 or IL-8. A slight IL-6 and IL-8 production by a Caco-2 cell was detected after exposure to 8 of the tested Bifidobacterium strains. No correlation was found between adhesion and cytokine induction among the bacteria tested. This indicates that lactic acid bacteria, even those with strong adhesive properties, are not very likely to trigger an inflammatory response in human enterocytes.
|
| 巻・号 |
46(4)
|
| ページ |
293-7
|
| 公開日 |
2002-1-1
|
| DOI |
10.1111/j.1348-0421.2002.tb02698.x
|
| PMID |
12061632
|
| MeSH |
Adult
Bacterial Adhesion / physiology*
Caco-2 Cells
Cytokines / metabolism*
Enterocytes / metabolism
Enterocytes / microbiology*
Humans
Infant
Interleukin-6 / biosynthesis
Interleukin-6 / metabolism
Interleukin-8 / biosynthesis
Interleukin-8 / metabolism
Lactobacillus / physiology*
|
| IF |
1.566
|
| 引用数 |
88
|
|
WOS 分野
|
MICROBIOLOGY
IMMUNOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
CACO-2(RCB0988) |
